Creatine is naturally produced in the human body from amino acids L-arginine, glycine, and L-methionine primarily in the kidney and liver and transported in the blood to help supply energy to all cells in the body. Creatine is metabolized into phosphocreatine, an important storage form used by the brain, heart, and skeletal muscles.*
Creatine MegaÂ® exerts various effects upon entering the muscle. It is these effects that elicit improvements in exercise performance and may be responsible for the improvements of muscle function and energy metabolism seen under certain conditions.*
Several mechanisms have been proposed to explain the increased exercise performance seen after creatine intake:
- *Optimizing energy metabolism by maintaining higher levels of the bodyâ€™s energy compound adenosine triphosphate or ATP.*
- *Increasing myofibrillar mRNA content and protein synthesis, and reducing amino acid oxidation and protein break-down.*
- *Increasing satellite cell and myonuclei number and activity in human skeletal muscle.*
- *Preventing tissue damage by stabilizing cellular membranes and maintaining reserves of ATP.*
*These statements have not been evaluated by the United States FDA. This product is not intended to diagnose, treat, cure or prevent any disease.